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SEC FORM 4 SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940 		 
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X
 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person*
Hatteras Venture Advisors III, LLC
(Last) (First) (Middle)
280 S. MANGUM STREET, SUITE 350
(Street)
DURHAM NC 27701
(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Clearside Biomedical, Inc. [ CLSD ] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director X 10% Owner
Officer (give title below) X Other (specify below)
May be part of a 13(d) Group
3. Date of Earliest Transaction (Month/Day/Year)
01/17/2017
4. If Amendment, Date of Original Filed (Month/Day/Year)
 6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 01/17/2017 S 8,366 D $8.92(1) 1,774,654 I See Footnote(2)
Common Stock 01/18/2017 S 10,457 D $8.64(3) 1,764,197 I See Footnote(2)
Common Stock 01/19/2017 S 6,478 D $8.22(4) 1,757,719 I See Footnote(2)(5)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
1. Name and Address of Reporting Person*
Hatteras Venture Advisors III, LLC
(Last) (First) (Middle)
280 S. MANGUM STREET, SUITE 350
(Street)
DURHAM NC 27701
(City) (State) (Zip)
1. Name and Address of Reporting Person*
Hatteras Ventures Partners III LP
(Last) (First) (Middle)
280 S. MANGUM STREET, SUITE 350
(Street)
DURHAM NC 27701
(City) (State) (Zip)
1. Name and Address of Reporting Person*
Hatteras Venture Affiliates III Lp
(Last) (First) (Middle)
280 S. MANGUM STREET, SUITE 350
(Street)
DURHAM NC 27701
(City) (State) (Zip)
1. Name and Address of Reporting Person*
Crumpler John
(Last) (First) (Middle)
C/O HATTERAS VENTURES
280 S. MANGUM STREET, SUITE 350
(Street)
DURHAM NC 27701
(City) (State) (Zip)
1. Name and Address of Reporting Person*
INGRAM ROBERT ALEXANDER
(Last) (First) (Middle)
C/O HATTERAS VENTURES
280 S. MANGUM STREET, SUITE 350
(Street)
DURHAM NC 27701
(City) (State) (Zip)
1. Name and Address of Reporting Person*
LEE KENNETH B JR
(Last) (First) (Middle)
C/O HATTERAS VENTURES
280 S. MANGUM STREET, SUITE 350
(Street)
DURHAM NC 27701
(City) (State) (Zip)
1. Name and Address of Reporting Person*
Reed Douglas MD
(Last) (First) (Middle)
C/O HATTERAS VENTURES
280 S. MANGUM STREET, SUITE 350
(Street)
DURHAM NC 27701
(City) (State) (Zip)
1. Name and Address of Reporting Person*
Thorp Clay
(Last) (First) (Middle)
C/O HATTERAS VENTURES
280 S. MANGUM STREET, SUITE 350
(Street)
DURHAM NC 27701
(City) (State) (Zip)
Explanation of Responses:
1. This transaction was executed in multiple trades at prices ranging from $8.68 to $9.22. The price reported in Column 4 is a weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transactions were effected.
2. The reportable securities are owned directly by Hatteras Venture Partners III, LP ("HVP") and Hatteras Venture Affiliates III, LP ("HVA"). Hatteras Venture Advisors III, LLC is the general partner of HVP and HVA (the "GP"). The shares directly held by HVP and HVA are indirectly held by the individual managing members of GP (each, a "GP Managing Member" and collectively, the "GP Managing Members"). The GP Managing Members are John Crumpler, Clay Thorp, Ken Lee, Douglas Reed and Robert Ingram. The GP Managing Members may share voting and dispositive power over the securities directly held by HVP and HVA. Each GP Managing Member disclaims beneficial ownership of these securities and this report is not an admission that any GP Managing Member is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein.
3. This transaction was executed in multiple trades at prices ranging from $8.42 to $8.79. The price reported in Column 4 is a weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transactions were effected.
4. This transaction was executed in multiple trades at prices ranging from $8.01 to $8.65. The price reported in Column 4 is a weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transactions were effected.
5. HVP holds 1,611,407 shares and HVA holds 146,312 shares of the Issuer's common stock directly.
/s/ Thomas A. Allen, attorney-in-fact for Hatteras Venture Advisors III, LLC 01/19/2017
/s/ Thomas A. Allen, attorney-in-fact for Hatteras Venture Advisors III, LLC, the general partner of Hatteras Venture Partners III, LP 01/19/2017
/s/ Thomas A. Allen, attorney-in-fact for Hatteras Venture Advisors III, LLC, the general partner of Hatteras Venture Affiliates III, LP 01/19/2017
/s/ Thomas A. Allen, attorney-in-fact for John C. Crumpler 01/19/2017
/s/ Thomas A. Allen, attorney-in-fact for Robert A. Ingram 01/19/2017
/s/ Thomas A. Allen, attorney-in-fact for Kenneth B. Lee 01/19/2017
/s/ Thomas A. Allen, attorney-in-fact for Douglas Reed 01/19/2017
/s/ Thomas A. Allen, attorney-in-fact for Clay B. Thorp 01/19/2017
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
POWER OF ATTORNEY

	Know all by these presents that the undersigned hereby
constitutes and appoints each of Thomas A. Allen and
Andrew J. Gibbons, and each of them acting alone, signing
singly, the undersigned's true and lawful attorney-in-fact
to:

(1) execute for and on behalf of the undersigned, in the
undersigned's capacity as an officer, director, and/or 10%
or more stockholder of Clearside Biomedical , Inc. (the
"Company"), Forms ID, 3, 4 and 5 and Schedules 13D or 13G
(and any amendments thereto) under Section 13(d) and 16(a)
of the Securities Exchange Act of 1934, as amended (the
"1934 Act") in accordance with the 1934 Act, and the rules
promulgated thereunder;

(2) do and perform any and all acts for and on behalf of the
undersigned which may be necessary or desirable to complete
and execute any such Form or Schedule (and any amendments
thereto) and to file timely such Form or Schedule with the
United States Securities and Exchange Commission and any
stock exchange or similar authority; and

(3) take any other action of any type whatsoever in connection
with the foregoing which in the opinion of such attorney-in-
fact may be of benefit to, in the best interest of, or
legally required by, the undersigned, it being understood that
the documents executed by such attorney-in-fact on behalf of
the undersigned pursuant to this Power of Attorney shall be in
such form and shall contain such terms and conditions as such
attorney-in-fact may approve in such attorney-in-fact's
discretion.

	The undersigned hereby grants to each such attorney-in-
fact full power and authority to do and perform any and every
act and thing whatsoever requisite, necessary or proper to be
done in the exercise of any of the rights and powers herein
granted, as fully to all intents and purposes as the
undersigned might or could do if personally present, with full
power of substitution or revocation, hereby ratifying and
confirming all that such attorney-in-fact, or such attorney-
in-fact's substitute or substitutes, shall lawfully do or
cause to be done by virtue of this power of attorney and the
rights and powers herein granted.  The undersigned acknowledges
that the foregoing attorneys-in-fact, in serving in such
capacity at the request of the undersigned, are not assuming,
nor is the Company assuming, any of the undersigned's
responsibilities to comply with Section 13(d) or 16(a) of the
1934 Act.

	This Power of Attorney shall remain in full force and
effect until the undersigned is no longer required to file such
Forms or Schedules with respect to the undersigned's holdings
of and transactions in securities issued by the Company, unless
earlier revoked by the undersigned in a signed writing
delivered to each of the foregoing attorneys-in-fact.

	IN WITNESS WHEREOF, the undersigned has caused this Power
of Attorney to be executed as of this 18th day of January 2017.


HATTERAS VENTURE ADVISORS III, LLC

By:  /s/ Clay B. Thorp
Name: 	Clay B. Thorp
Title: 	Manager


HATTERAS VENTURE PARTNERS III, LP

By:  Hatteras Venture Advisors III, LLC, its general
partner

By:  /s/ Clay B. Thorp
Name: 	Clay B. Thorp
Title: 	Manager


HATTERAS VENTURE AFFILIATES III, LP

By:  Hatteras Venture Advisors III, LLC, its general
partner

By:  /s/ Clay B. Thorp
Name: 	Clay B. Thorp
Title: 	Manager


/s/ John C. Crumpler
John C. Crumpler


/s/ Robert A. Ingram
Robert A. Ingram


/s/ Kenneth B. Lee
Kenneth B. Lee


/s/ Douglas Reed
Douglas Reed


/s/ Clay B. Thorp
Clay B. Thorp