00000 - Document - Template Link link:presentationLink link:calculationLink link:definitionLink 100000 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 100010 - Statement - Balance Sheets link:calculationLink link:presentationLink link:definitionLink 100020 - Statement - Balance Sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 100030 - Statement - Statements of Operations and Comprehensive Loss link:calculationLink link:presentationLink link:definitionLink 100040 - Statement - Statements of Cash Flows link:calculationLink link:presentationLink link:definitionLink 100050 - Disclosure - The Company link:calculationLink link:presentationLink link:definitionLink 100060 - Disclosure - Significant Accounting Policies link:calculationLink link:presentationLink link:definitionLink 100070 - Disclosure - Property and Equipment, Net link:calculationLink link:presentationLink link:definitionLink 100080 - Disclosure - Accrued Liabilities link:calculationLink link:presentationLink link:definitionLink 100090 - Disclosure - Long-Term Debt link:calculationLink link:presentationLink link:definitionLink 100100 - Disclosure - Common Stock link:calculationLink link:presentationLink link:definitionLink 100110 - Disclosure - Stock Purchase Warrants link:calculationLink link:presentationLink link:definitionLink 100120 - Disclosure - Share-Based Compensation link:calculationLink link:presentationLink link:definitionLink 100130 - Disclosure - Commitment and Contingencies link:calculationLink link:presentationLink link:definitionLink 100140 - Disclosure - License and Collaboration Agreements link:calculationLink link:presentationLink link:definitionLink 100150 - Disclosure - Available-for-Sale Investments link:calculationLink link:presentationLink link:definitionLink 100160 - Disclosure - Fair Value Measurements link:calculationLink link:presentationLink link:definitionLink 100170 - Disclosure - Net Loss per Share link:calculationLink link:presentationLink link:definitionLink 100180 - Disclosure - Subsequent Event link:calculationLink link:presentationLink link:definitionLink 100190 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:presentationLink link:definitionLink 100200 - Disclosure - Significant Accounting Policies (Tables) link:calculationLink link:presentationLink link:definitionLink 100210 - Disclosure - Property and Equipment, Net (Tables) link:calculationLink link:presentationLink link:definitionLink 100220 - Disclosure - Accrued Liabilities (Tables) link:calculationLink link:presentationLink link:definitionLink 100230 - Disclosure - Long-Term Debt (Tables) link:calculationLink link:presentationLink link:definitionLink 100240 - Disclosure - Share-Based Compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 100250 - Disclosure - Commitment and Contingencies (Tables) link:calculationLink link:presentationLink link:definitionLink 100260 - Disclosure - Available-for-Sale Investments (Tables) link:calculationLink link:presentationLink link:definitionLink 100270 - Disclosure - Fair Value Measurements (Tables) link:calculationLink link:presentationLink link:definitionLink 100280 - Disclosure - Net Loss per Share (Tables) link:calculationLink link:presentationLink link:definitionLink 100290 - Disclosure - The Company - Additional Information (Details) link:calculationLink link:presentationLink link:definitionLink 100300 - Disclosure - Significant Accounting Policies - Additional Information (Details) link:calculationLink link:presentationLink link:definitionLink 100310 - Disclosure - Significant Accounting Policies - Schedule on Reconciliation of Cash and Cash Equivalents and Restricted Cash (Details) link:calculationLink link:presentationLink link:definitionLink 100320 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Details) link:calculationLink link:presentationLink link:definitionLink 100330 - Disclosure - Accrued Liabilities - Schedule of Accrued Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 100340 - Disclosure - Long-Term Debt - Additional Information (Details) link:calculationLink link:presentationLink link:definitionLink 100350 - Disclosure - Long-Term Debt - Scheduled Payments for Loan Agreement (Details) link:calculationLink link:presentationLink link:definitionLink 100360 - Disclosure - Common Stock - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100370 - Disclosure - Stock Purchase Warrants - Additional Information (Details) link:calculationLink link:presentationLink link:definitionLink 100380 - Disclosure - Share-Based Compensation - Summary of Share-based Compensation Expense (Details) link:calculationLink link:presentationLink link:definitionLink 100390 - Disclosure - Share-Based Compensation - Summary of Activity Related to Stock Options (Details) link:calculationLink link:presentationLink link:definitionLink 100400 - Disclosure - Share-Based Compensation - Additional Information (Details) link:calculationLink link:presentationLink link:definitionLink 100410 - Disclosure - Commitment and Contingencies - Additional Information (Details) link:calculationLink link:presentationLink link:definitionLink 100420 - Disclosure - Commitment and Contingencies - Total Future Minimum Commitments Due Under Non-Cancelable Operating Leases (Details) link:calculationLink link:presentationLink link:definitionLink 100430 - Disclosure - License and Collaboration Agreements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100440 - Disclosure - Available-for-Sale Investments - Summary of Company's Available-For-Sale Investments (Details) link:calculationLink link:presentationLink link:definitionLink 100450 - Disclosure - Fair Value Measurements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 100460 - Disclosure - Fair Value Measurements - Summary of Assets Measured at Fair Value (Detail) link:calculationLink link:presentationLink link:definitionLink 100470 - Disclosure - Net Loss Per Share - Potential Common Stock Equivalents Excluded from Computation of Diluted Net Loss per Share (Details) link:calculationLink link:presentationLink link:definitionLink 100480 - Disclosure - Subsequent Event - Additional Information (Details) link:calculationLink link:presentationLink link:definitionLink