101 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink 103 - Statement - Balance sheets link:calculationLink link:presentationLink link:definitionLink 104 - Statement - Balance sheets (Parenthetical) link:calculationLink link:presentationLink link:definitionLink 105 - Statement - Statements of operations and comprehensive loss link:calculationLink link:presentationLink link:definitionLink 106 - Statement - Statements of stockholders' deficit link:calculationLink link:presentationLink link:definitionLink 107 - Statement - Statements of cash flows link:calculationLink link:presentationLink link:definitionLink 108 - Disclosure - The company link:calculationLink link:presentationLink link:definitionLink 109 - Disclosure - Significant accounting policies link:calculationLink link:presentationLink link:definitionLink 110 - Disclosure - Net loss per share link:calculationLink link:presentationLink link:definitionLink 111 - Disclosure - Property and equipment, net link:calculationLink link:presentationLink link:definitionLink 112 - Disclosure - Accrued liabilities link:calculationLink link:presentationLink link:definitionLink 113 - Disclosure - Long-term debt link:calculationLink link:presentationLink link:definitionLink 114 - Disclosure - Convertible shareholder notes payable link:calculationLink link:presentationLink link:definitionLink 115 - Disclosure - Income taxes link:calculationLink link:presentationLink link:definitionLink 116 - Disclosure - Convertible debt link:calculationLink link:presentationLink link:definitionLink 117 - Disclosure - Common stock link:calculationLink link:presentationLink link:definitionLink 118 - Disclosure - Stock purchase warrants link:calculationLink link:presentationLink link:definitionLink 119 - Disclosure - Share-based compensation link:calculationLink link:presentationLink link:definitionLink 120 - Disclosure - Commitments and contingencies link:calculationLink link:presentationLink link:definitionLink 121 - Disclosure - License agreements link:calculationLink link:presentationLink link:definitionLink 122 - Disclosure - Collaborative agreement link:calculationLink link:presentationLink link:definitionLink 123 - Disclosure - Fair value measurements link:calculationLink link:presentationLink link:definitionLink 124 - Disclosure - Subsequent events link:calculationLink link:presentationLink link:definitionLink 125 - Disclosure - Available-for sale securities link:calculationLink link:presentationLink link:definitionLink 126 - Disclosure - Significant accounting policies (Policies) link:calculationLink link:presentationLink link:definitionLink 127 - Disclosure - Significant accounting policies (Tables) link:calculationLink link:presentationLink link:definitionLink 128 - Disclosure - Property and equipment, net (Tables) link:calculationLink link:presentationLink link:definitionLink 129 - Disclosure - Accrued liabilities (Tables) link:calculationLink link:presentationLink link:definitionLink 130 - Disclosure - Long-term debt (Tables) link:calculationLink link:presentationLink link:definitionLink 131 - Disclosure - Income taxes (Tables) link:calculationLink link:presentationLink link:definitionLink 132 - Disclosure - Convertible debt (Tables) link:calculationLink link:presentationLink link:definitionLink 133 - Disclosure - Stock purchase warrants (Tables) link:calculationLink link:presentationLink link:definitionLink 134 - Disclosure - Share-based compensation (Tables) link:calculationLink link:presentationLink link:definitionLink 135 - Disclosure - Commitments and contingencies (Tables) link:calculationLink link:presentationLink link:definitionLink 136 - Disclosure - Fair value measurements (Tables) link:calculationLink link:presentationLink link:definitionLink 137 - Disclosure - Available-for sale securities (Tables) link:calculationLink link:presentationLink link:definitionLink 138 - Disclosure - The Company - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 139 - Disclosure - Significant Accounting Policies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 140 - Disclosure - Net Loss Per Share - Potential Common Stock Equivalents Excluded from Computation of Diluted Net Loss per Share (Detail) link:calculationLink link:presentationLink link:definitionLink 141 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Detail) link:calculationLink link:presentationLink link:definitionLink 142 - Disclosure - Accrued Liabilities - Schedule of Accrued Liabilities (Detail) link:calculationLink link:presentationLink link:definitionLink 143 - Disclosure - Long-Term Debt - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 144 - Disclosure - Long-Term Debt - Scheduled Payments for Loan Agreement (Detail) link:calculationLink link:presentationLink link:definitionLink 145 - Disclosure - Convertible Shareholder Notes Payable (Detail) link:calculationLink link:presentationLink link:definitionLink 146 - Disclosure - Schedule of Net Deferred Tax Assets (Detail) link:calculationLink link:presentationLink link:definitionLink 147 - Disclosure - Schedule of Statutory and Effective Income Tax Rate Reconciliation (Detail) link:calculationLink link:presentationLink link:definitionLink 148 - Disclosure - Income Tax - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 149 - Disclosure - Convertible Preferred Stock - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 150 - Disclosure - Convertible Preferred Stock (Detail) link:calculationLink link:presentationLink link:definitionLink 151 - Disclosure - Convertible Preferred Stock (Parenthetical) (Detail) link:calculationLink link:presentationLink link:definitionLink 152 - Disclosure - Common Stock - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 153 - Disclosure - Stock Purchase Warrants - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 154 - Disclosure - Assumptions Utilized in Fair Value Calculation for Warrants (Detail) link:calculationLink link:presentationLink link:definitionLink 155 - Disclosure - Share-Based Compensation - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 156 - Disclosure - Share-Based Compensation - Summary of Share-based Compensation Expense (Detail) link:calculationLink link:presentationLink link:definitionLink 157 - Disclosure - Share-Based Compensation - Weighted Average Assumptions Used in Fair Value Calculation for Underlying Common Stock (Detail) link:calculationLink link:presentationLink link:definitionLink 158 - Disclosure - Share-Based Compensation - Summary of Activity Related to Stock Options (Detail) link:calculationLink link:presentationLink link:definitionLink 159 - Disclosure - Share-Based Compensation - Additional Information about the Stock Option Outstanding and Exercisable (Detail) link:calculationLink link:presentationLink link:definitionLink 160 - Disclosure - Summary of the Unvested Restricted Stock (Detail) link:calculationLink link:presentationLink link:definitionLink 161 - Disclosure - Commitment and Contingencies - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 162 - Disclosure - Commitment and Contingencies - Future Minimum Commitments Due Under Non-Cancelable Operating Leases (Detail) link:calculationLink link:presentationLink link:definitionLink 163 - Disclosure - License Agreements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 164 - Disclosure - Collaborative Agreement - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 165 - Disclosure - Fair Value Measurements - Summary of Assets and Liabilities Measured at Fair Value (Detail) link:calculationLink link:presentationLink link:definitionLink 166 - Disclosure - Fair Value Measurements - Summarizes the Changes in Fair Value of the Level 3 Liability, Stock Purchase Warrants (Detail) - Stock Purchase Warrants (Detail) link:calculationLink link:presentationLink link:definitionLink 167 - Disclosure - Subsequent Events - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink 168 - Disclosure - Convertible Debt (Detail) link:calculationLink link:presentationLink link:definitionLink 169 - Disclosure - Available-for Sale Securities - Summary of Company's Available-For-Sale Investments (Detail) link:calculationLink link:presentationLink link:definitionLink 170 - Disclosure - Fair Value Measurements - Additional Information (Detail) link:calculationLink link:presentationLink link:definitionLink