Entity Central Index Key Document And Entity Information [Abstract] Document And Entity Information [Abstract] Entity Registrant Name Entity Registrant Name Amendment Flag Amendment Flag Document Period End Date Document Period End Date Document Fiscal Year Focus Document Fiscal Year Focus Document Fiscal Period Focus Document Fiscal Period Focus Trading Symbol Trading Symbol Document Type Document Type Entity Central Index Key Current Fiscal Year End Date Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Well Known Seasoned Issuer Entity Current Reporting Status Entity Current Reporting Status Entity Voluntary Filers Entity Voluntary Filers Entity Filer Category Entity Filer Category Entity Small Business Entity Small Business Entity Emerging Growth Company Entity Emerging Growth Company Entity Ex Transition Period Entity Ex Transition Period Entity Shell Company Entity Shell Company Entity Common Stock, Shares Outstanding Entity Common Stock Shares Outstanding Entity Public Float Entity Public Float Statement Of Financial Position [Abstract] Assets Assets [Abstract] Current assets: Assets Current [Abstract] Cash and cash equivalents Cash And Cash Equivalents At Carrying Value Short-term investments Available For Sale Securities Debt Securities Current Prepaid expenses Prepaid Expense Current Other current assets Other Assets Current Total current assets Assets Current Property and equipment, net Property Plant And Equipment Net Restricted cash Restricted Cash And Cash Equivalents Noncurrent Other assets Other Assets Noncurrent Total assets Assets Liabilities, convertible preferred stock and stockholders’ equity Liabilities And Stockholders Equity [Abstract] Current liabilities: Liabilities Current [Abstract] Accounts payable Accounts Payable Current Accrued liabilities Accrued Liabilities Current Current portion of long-term debt Long Term Debt Current Current portion of deferred rent Deferred Rent Credit Current Other current liabilities Other Liabilities Current Total current liabilities Liabilities Current Long-term debt Long Term Debt Noncurrent Deferred rent Deferred Rent Credit Noncurrent Deferred revenue Deferred Revenue Noncurrent Total liabilities Liabilities Commitments and contingencies Commitments And Contingencies Stockholders’ equity: Stockholders Equity [Abstract] Preferred stock, $0.001 par value; 10,000,000 shares authorized and no shares issued at December 31, 2018 and 2017 Preferred Stock Value Common stock, $0.001 par value; 100,000,000 shares authorized at December 31, 2018 and 2017; 32,119,227 and 25,354,651 shares issued and outstanding at December 31, 2018 and 2017, respectively Common Stock Value Additional paid-in capital Additional Paid In Capital Accumulated deficit Retained Earnings Accumulated Deficit Accumulated other comprehensive loss Accumulated Other Comprehensive Income Loss Net Of Tax Total stockholders’ equity Stockholders Equity Total liabilities and stockholders’ equity Liabilities And Stockholders Equity Preferred stock, par value Preferred Stock Par Or Stated Value Per Share Preferred stock, shares authorized Preferred Stock Shares Authorized Preferred stock, shares issued Preferred Stock Shares Issued Common stock, par value Common Stock Par Or Stated Value Per Share Common stock, shares authorized Common Stock Shares Authorized Common stock, shares, issued Common Stock Shares Issued Common stock, shares outstanding Common Stock Shares Outstanding Income Statement [Abstract] License and collaboration revenue Revenue From Contract With Customer Excluding Assessed Tax Type of Revenue [Extensible List] Type Of Revenue Extensible List Operating expenses: Operating Expenses [Abstract] Research and development Research And Development Expense General and administrative General And Administrative Expense Total operating expenses Operating Expenses Loss from operations Operating Income Loss Other income (expense) Nonoperating Income Expense Net loss Net Income Loss Net loss per share of common stock — basic and diluted Earnings Per Share Basic And Diluted Weighted average shares outstanding — basic and diluted Weighted Average Number Of Share Outstanding Basic And Diluted Net loss Unrealized gain (loss) on available-for-sale investments Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax Comprehensive loss Comprehensive Income Net Of Tax Restricted Stock Vested Restricted Stock Vested Value Issuance of common stock upon exercise of warrants shares. Issuance of common stock upon exercise of warrants. Stock issued during period shares follow on offering. Stock issued during period value follow on offering. Issuance of warrant to purchase common stock. Statement Of Stockholders Equity [Abstract] Statement [Table] Statement [Table] Equity Components Statement Equity Components [Axis] Equity Component Equity Component [Domain] Common Stock Common Stock [Member] Additional Paid-In-Capital Additional Paid In Capital [Member] Accumulated Deficit Retained Earnings [Member] Accumulated Other Comprehensive Loss Accumulated Other Comprehensive Income [Member] Class of Stock Statement Class Of Stock [Axis] Class of Stock Class Of Stock [Domain] Redeemable Convertible Preferred Stock Redeemable Convertible Preferred Stock [Member] Statement [Line Items] Statement [Line Items] Beginning balance Beginning balance, shares Shares Outstanding Cumulative effect of accounting change Cumulative Effect On Retained Earnings Net Of Tax1 Issuance of common shares under employee stock purchase plan Stock Issued During Period Value Employee Stock Purchase Plan Issuance of common shares under employee stock purchase plan, shares Stock Issued During Period Shares Employee Stock Purchase Plans Exercise of stock options Stock Issued During Period Value Stock Options Exercised Exercise of stock options, shares Stock Issued During Period Shares Stock Options Exercised Vesting of restricted stock Restricted Stock Vested Value Vesting of restricted stock, shares Restricted Stock Vested Issuance of common stock upon exercise of warrants Issuance Of Common Stock Upon Exercise Of Warrants Issuance of common stock upon exercise of warrants, Shares Issuance Of Common Stock Upon Exercise Of Warrants Shares Issuance of common stock in initial public offering Stock Issued During Period Value New Issues Issuance of common stock in initial public offering, Shares Stock Issued During Period Shares New Issues Issuance of common stock in follow-on offering Stock Issued During Period Value Follow On Offering Issuance of common stock in follow-on offering, Shares Stock Issued During Period Shares Follow On Offering Conversion of preferred stock to common stock Stock Issued During Period Value Conversion Of Convertible Securities Net Of Adjustments Conversion of preferred stock to common stock, Shares Stock Issued During Period Shares Conversion Of Convertible Securities Issuance of warrants to purchase common stock Issuance Of Warrant To Purchase Common Stock Other comprehensive gain (loss) Other Comprehensive Income Loss Net Of Tax Accretion of stock issuance costs Preferred Stock Accretion Of Redemption Discount Share-based compensation expense Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value Ending balance Ending balance, shares Increase (decrease) in deferred rent. Proceeds from issuance follow on offering. Noncash tenant improvements paid by landlord. Reclassification of deferred initial public offering costs. Accretion of redeemable convertible preferred stock to redemption value. Deferred initial public offering costs in accounts payable and accrued expenses. Statement Of Cash Flows [Abstract] Operating activities Net Cash Provided By Used In Operating Activities [Abstract] Net loss Profit Loss Adjustments to reconcile net loss to net cash used in operating activities: Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract] Depreciation Depreciation Share-based compensation expense Share Based Compensation Non-cash interest expense Paid In Kind Interest Accretion of debt discount Deferred Finance Costs Own Share Lending Arrangement Issuance Costs Amortization Expense1 Change in fair value of warrant liability Fair Value Adjustment Of Warrants Amortization and accretion on available-for-sale investments, net Accretion Amortization Of Discounts And Premiums Investments Changes in operating assets and liabilities: Increase Decrease In Operating Capital [Abstract] Prepaid expenses and other current assets Increase Decrease In Prepaid Deferred Expense And Other Assets Other assets Increase Decrease In Other Operating Assets Accounts payable and accrued liabilities Increase Decrease In Accounts Payable And Accrued Liabilities Deferred revenue Increase Decrease In Contract With Customer Liability Deferred rent Increase Decrease In Deferred Rent Net cash used in operating activities Net Cash Provided By Used In Operating Activities Investing activities Net Cash Provided By Used In Investing Activities [Abstract] Purchase of available-for-sale investments Payments To Acquire Available For Sale Securities Debt Maturities of available-for-sale-investments Proceeds From Sale And Maturity Of Available For Sale Securities Change in restricted cash Increase Decrease In Restricted Cash Acquisition of property and equipment Payments To Acquire Property Plant And Equipment Net cash (used in) provided by investing activities Net Cash Provided By Used In Investing Activities Financing activities Net Cash Provided By Used In Financing Activities [Abstract] Proceeds from follow-on offering, net of issuance costs Proceeds From Issuance Follow On Offering Proceeds from initial public offering, net of issuance costs Proceeds From Issuance Initial Public Offering Proceeds from exercise of stock options Proceeds From Stock Options Exercised Proceeds from shares issued under employee stock purchase plan Proceeds From Issuance Of Shares Under Incentive And Share Based Compensation Plans Proceeds from issuance of long-term debt Proceeds From Issuance Of Long Term Debt Principal payments made on long-term debt Repayments Of Long Term Debt Net cash provided by financing activities Net Cash Provided By Used In Financing Activities Net (decrease) increase in cash, cash equivalents and restricted cash Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect Cash, cash equivalents and restricted cash, beginning of period Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Cash, cash equivalents and restricted cash, end of period Supplemental disclosure Supplemental Cash Flow Information [Abstract] Interest paid Interest Paid Net Tenant improvements paid by landlord Noncash Tenant Improvements Paid By Landlord Conversion of convertible preferred stock to common stock Conversion Of Stock Amount Converted1 Reclassification of deferred initial public offering costs Reclassification Of Deferred Initial Public Offering Costs Accretion of redeemable convertible preferred stock to redemption value Accretion Of Redeemable Convertible Preferred Stock To Redemption Value Unpaid initial public offering costs in accounts payable and accrued expenses Deferred Initial Public Offering Costs In Accounts Payable And Accrued Expenses Organization Consolidation And Presentation Of Financial Statements [Abstract] The Company Organization Consolidation And Presentation Of Financial Statements Disclosure [Text Block] Accounting Policies [Abstract] Significant Accounting Policies Significant Accounting Policies [Text Block] Property Plant And Equipment [Abstract] Property and Equipment, Net Property Plant And Equipment Disclosure [Text Block] Payables And Accruals [Abstract] Accrued Liabilities Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block] Debt Disclosure [Abstract] Long-Term Debt Long Term Debt [Text Block] Equity [Abstract] Preferred and Common Stock Stockholders Equity Note Disclosure [Text Block] Common stock warrants disclosure. Common stock warrants abstract. Common Stock Warrants [Abstract] Common Stock Warrants Common Stock Warrants Disclosure [Text Block] Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] Share-Based Compensation Disclosure Of Compensation Related Costs Share Based Payments [Text Block] Income Tax Disclosure [Abstract] Income Taxes Income Tax Disclosure [Text Block] Commitments And Contingencies Disclosure [Abstract] Commitments and Contingencies Commitments And Contingencies Disclosure [Text Block] License and collaboration agreements disclosure. License and collaboration agreements. License And Collaboration Agreements [Abstract] License and Collaboration Agreements License And Collaboration Agreements Disclosure [Text Block] Investments, Debt and Equity Securities [Abstract] Available-for-Sale Investments Investments In Debt And Marketable Equity Securities And Certain Trading Assets Disclosure [Text Block] Fair Value Disclosures [Abstract] Fair Value Measurements Fair Value Disclosures [Text Block] Earnings Per Share [Abstract] Net Loss Per Share Earnings Per Share [Text Block] Quarterly Financial Data [Abstract] Quarterly Financial Information (Unaudited) Quarterly Financial Information [Text Block] Basis of Presentation Basis Of Accounting Policy Policy [Text Block] Use of Estimates Use Of Estimates Segment Information Segment Reporting Policy Policy [Text Block] Property and Equipment, Net Property Plant And Equipment Policy [Text Block] Debt Discount Debt Policy [Text Block] Fair Value Measurements Fair Value Measurement Policy Policy [Text Block] Income Taxes Income Tax Policy [Text Block] Research and Development Costs Research And Development Expense Policy Share-Based Compensation Compensation Related Costs Policy [Text Block] Cash Equivalents Cash And Cash Equivalents Policy [Text Block] Short-Term Investments Marketable Securities Policy Restricted Cash Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy Concentration of Credit Risk Arising From Cash Deposits in Excess of Insured Limits Concentration Risk Credit Risk Recent Accounting Pronouncements New Accounting Pronouncements Policy Policy [Text Block] Schedule of cash and cash equivalents and restricted cash. Schedule of Reconciliation of Cash and Cash Equivalents and Restricted Cash Schedule Of Cash And Cash Equivalents And Restricted Cash Table [Text Block] Schedule of Property and Equipment, Net Property Plant And Equipment [Text Block] Schedule of Accrued Liabilities Schedule Of Accrued Liabilities Table [Text Block] Scheduled Payments for the Loan Agreement Schedule Of Maturities Of Long Term Debt Table [Text Block] Plan Name Plan Name [Axis] Plan Name Plan Name [Domain] Two thousand sixteen employee stock purchase plan. 2016 Employee Stock Purchase Plan Two Thousand Sixteen Employee Stock Purchase Plan [Member] Summary of Share-based Compensation Expense Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block] Weighted Average Assumptions Used in Fair Value Calculation for Underlying Common Stock Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block] Summary of Activity Related to Stock Options Schedule Of Share Based Compensation Stock Options Activity Table [Text Block] Additional Information about the Stock Option Outstanding and Exercisable Schedule Of Share Based Compensation Stock Options And Stock Appreciation Rights Award Activity Table [Text Block] Schedule of Net Deferred Tax Assets Schedule Of Deferred Tax Assets And Liabilities Table [Text Block] Schedule of Statutory and Effective Income Tax Rate Reconciliation Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block] Future Minimum Commitments Due Under Non-Cancelable Operating Leases Schedule Of Future Minimum Rental Payments For Operating Leases Table [Text Block] Summary of Company's Available-For-Sale Investments Debt Securities Available For Sale Table [Text Block] Summary of Assets and Liabilities Measured at Fair Value Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Table [Text Block] Potential Common Stock Equivalents Excluded from Computation of Diluted Net Loss per Share Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block] Summary of Quarterly Financial Information Schedule Of Quarterly Financial Information Table [Text Block] Organization consolidation and presentation of financial statements disclosure lineItems. Organization consolidation and presentation of financial statements disclosure table. Organization Consolidation And Presentation Of Financial Statements Disclosure [Table] Organization Consolidation And Presentation Of Financial Statements Disclosure [Table] Sale of Stock Subsidiary Sale Of Stock [Axis] Sale of Stock Sale Of Stock Name Of Transaction [Domain] IPO I P O [Member] Over-allotment option by underwriters Over Allotment Option [Member] At-the-market sales agreement. At-the-market sales agreement At The Market Sales Agreement [Member] Counterparty Name Counterparty Name [Axis] Counterparty Name Repurchase Agreement Counterparty Name [Domain] Cowen and company llc. Cowen and Company LLC Cowen And Company L L C [Member] Range Range [Axis] Range Range [Member] Maximum Maximum [Member] Minimum [Member] Minimum [Member] Subsequent Event Type Subsequent Event Type [Axis] Subsequent Event Type Subsequent Event Type [Domain] Subsequent Event Subsequent Event [Member] Lender Name Line Of Credit Facility [Axis] Line of Credit Facility, Lender Line Of Credit Facility Lender [Domain] Silicon Valley Bank, MidCap funding III trust and MidCap financial trust. Silicon Valley Bank, MidCap Funding III Trust and MidCap Financial Trust Silicon Valley Bank Mid Cap Funding I I I Trust And Mid Cap Financial Trust [Member] Silicon Valley Bank, MidCap funding XII trust and MidCap financial trust. Silicon Valley Bank, MidCap Funding XII Trust and MidCap Financial Trust Silicon Valley Bank Mid Cap Funding X I I Trust And Mid Cap Financial Trust [Member] Credit Facility Credit Facility [Axis] Credit Facility Credit Facility [Domain] Final payment. Final Payment Final Payment [Member] Term C loan. Term C Loan Term C Loan [Member] Debt Instrument, Redemption, Period Debt Instrument Redemption Period [Axis] Debt Instrument, Redemption, Period Debt Instrument Redemption Period [Domain] Prepayment Prior the First Anniversary Debt Instrument Redemption Period Two [Member] Prepayment on or After First Anniversary but Prior to October 1, 2022 Debt Instrument Redemption Period Three [Member] Debt Instrument Debt Instrument [Axis] Debt Instrument, Name Debt Instrument Name [Domain] Second amended and restated loan and security agreement. Second Amended and Restated Loan and Security Agreement Second Amended And Restated Loan And Security Agreement [Member] Second amended and restated loan and security agreement, first tranche. First Amended and Restated Loan and Security Agreement, Initial Tranche Second Amended And Restated Loan And Security Agreement First Tranche [Member] First amended and restated loan and security agreement. First Amended and Restated Loan and Security Agreement First Amended And Restated Loan And Security Agreement [Member] Organization Consolidation and Presentation of Financial Statements Disclosure [Line Items] Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] Entity incorporation date Entity Incorporation Date Of Incorporation Initial public offering closing date. Net proceeds from issuance of stock. IPO, closing date Initial Public Offering Closing Date Net proceeds from issuance of stock Net Proceeds From Issuance Of Stock Public offering closing date. Public offering closing date Public Offering Closing Date Issuance of common stock for follow-on public offering, value Number of shares sold under facility Sale Of Stock Number Of Shares Issued In Transaction Net proceeds after deducting underwriting discounts and commissions and estimated offering expenses. Issuance of common stock for follow-on public offering, shares Common stock, Share offering price Sale Of Stock Price Per Share Net proceeds after deducting underwriting discounts and commissions and estimated offering expenses Net Proceeds After Deducting Underwriting Discounts And Commissions And Estimated Offering Expenses Line of credit facility remaining borrowing capacity not available for withdraw. Prepayment fee percentage of original principal amount of the each term loan. Debt instrument final payment percentage. Line of credit facility, maximum borrowing capacity Line Of Credit Facility Maximum Borrowing Capacity Fixed interest rate Debt Instrument Interest Rate Stated Percentage Debt instrument, description of variable rate basis Debt Instrument Description Of Variable Rate Basis Variable interest rate Debt Instrument Basis Spread On Variable Rate1 Long term debt Long Term Debt Repay all the amount outstanding under the amended and restated loan Repayments Of Debt Line of credit facility remaining borrowing capacity not available for withdraw Line Of Credit Facility Remaining Borrowing Capacity Not Available For Withdraw Line of credit facility, remaining borrowing capacity Line Of Credit Facility Remaining Borrowing Capacity Debt instrument, maturity date Debt Instrument Maturity Date Prepayment fee percentage of the original principal amount of the each term loan Prepayment Fee Percentage Of Original Principal Amount Of The Each Term Loan Final payment during maturity, percentage Debt Instrument Final Payment Percentage Cash, cash equivalents and short-term investments Cash Cash Equivalents And Short Term Investments Significant accounting policies. Significant Accounting Policies [Table] Significant Accounting Policies [Table] Significant Accounting Policies [Table] Adjustments for New Accounting Pronouncements Adjustments For New Accounting Pronouncements [Axis] Type of Adoption Type Of Adoption [Member] ASU 2014-09 Accounting Standards Update201409 [Member] Significant Accounting Policies [Line Items] Significant Accounting Policies [Line Items] Number of operating segments Number Of Operating Segments Short term investments, maturity period range start. Short term investments, maturity period range end. Short-term investments maturity start period Short Term Investments Maturity Period Range Start Short-term investments maturity end period Short Term Investments Maturity Period Range End Cumulative adjustment to accumulated deficit Cash And Cash Equivalents [Abstract] Cash, cash equivalents and restricted cash shown on the statements of cash flows Schedule Of Property Plant And Equipment [Table] Schedule Of Property Plant And Equipment [Table] Property, Plant and Equipment, Type Property Plant And Equipment By Type [Axis] Property, Plant and Equipment, Type Property Plant And Equipment Type [Domain] Furniture and Fixtures Furniture And Fixtures [Member] Machinery and Equipment Machinery And Equipment [Member] Computer Equipment Computer Equipment [Member] Leasehold Improvements Leasehold Improvements [Member] Property Plant And Equipment [Line Items] Property Plant And Equipment [Line Items] Property and Equipment, gross Property Plant And Equipment Gross Less: Accumulated depreciation Accumulated Depreciation Depletion And Amortization Property Plant And Equipment Property and equipment, net Estimated Useful Lives (Years) Property Plant And Equipment Useful Life Estimated Useful Lives (Years) Property Plant And Equipment Estimated Useful Lives Accrued research and development expenses. Accrued research and development Accrued Research And Development Expenses Accrued bonuses Accrued Bonuses Current Accrued professional fees Accrued Professional Fees Current Accrued vacation Accrued Vacation Current Accrued interest payable Interest Payable Current Accrued expense Other Accrued Liabilities Current Accrued liabilities, current Debt Instruments [Abstract] Debt Instrument [Table] Debt Instrument [Table] Prepayment Through May 31, 2020 Debt Instrument Redemption Period One [Member] Debt Instrument [Line Items] Debt Instrument [Line Items] Prepayment fee percentage of original principal amount of the aggregate term loans. Debt Instrument, Payment Terms Debt Instrument Payment Terms Prepayment fee percentage of the original principal amount of the aggregate term loans Prepayment Fee Percentage Of Original Principal Amount Of The Aggregate Term Loans Final payment during maturity Debt Instrument Periodic Payment Terms Balloon Payment To Be Paid Repay all the amount outstanding under the loan agreement including fees Accretion of final payment of amount borrowed. Accretion of deferred closing costs. Interest expense on borrowings Interest Expense Borrowings Accretion of scheduled final payment Accretion Of Final Payment Of Amount Borrowed Accretion of deferred closing costs Accretion Of Deferred Closing Costs Long term debt maturities repayments of principal, interest and final payment. Long term debt maturities repayments of principal, interest and final payment in next twelve months. Long term debt maturities repayments of principal, interest and final payment in year two. Long term debt maturities repayments of principal, interest and final payment in year three. Long term debt maturities repayments of principal interest and final payment in year four. Long term debt maturities repayments of interest and final payment. Long term debt maturities repayments of interest and final payment in next twelve months. Long term debt maturities repayments of interest and final payment in year two. Long term debt maturities repayments of interest and final payment in year three. Long term debt maturities repayments of interest and final payment in year four. Principal, 2019 Long Term Debt Maturities Repayments Of Principal In Next Twelve Months Principal, 2020 Long Term Debt Maturities Repayments Of Principal In Year Two Principal, 2021 Long Term Debt Maturities Repayments Of Principal In Year Three Principal, 2022 Long Term Debt Maturities Repayments Of Principal In Year Four Principal Interest and Final Payment, 2019 Long Term Debt Maturities Repayments Of Interest And Final Payment In Next Twelve Months Interest and Final Payment, 2020 Long Term Debt Maturities Repayments Of Interest And Final Payment In Year Two Interest and Final Payment, 2021 Long Term Debt Maturities Repayments Of Interest And Final Payment In Year Three Interest and Final Payment, 2022 Long Term Debt Maturities Repayments Of Interest And Final Payment In Year Four Interest and Final Payment Long Term Debt Maturities Repayments Of Interest And Final Payment Total, 2019 Long Term Debt Maturities Repayments Of Principal Interest And Final Payment In Next Twelve Months Total, 2020 Long Term Debt Maturities Repayments Of Principal Interest And Final Payment In Year Two Total, 2021 Long Term Debt Maturities Repayments Of Principal Interest And Final Payment In Year Three Total, 2022 Long Term Debt Maturities Repayments Of Principal Interest And Final Payment In Year Four Total Long Term Debt Maturities Repayments Of Principal Interest And Final Payment Preferred stock, shares outstanding Preferred Stock Shares Outstanding Warrants expiration term. Class Of Warrant Or Right [Table] Class Of Warrant Or Right [Table] Common stock warrants. Convertible Stock Warrant Common Stock Warrants [Member] Class Of Warrant Or Right [Line Items] Class Of Warrant Or Right [Line Items] Number of stock that can be purchased by each warrant Class Of Warrant Or Right Number Of Securities Called By Each Warrant Or Right Class of warrant Exercise Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1 Warrants expiration term Warrants Expiration Term Weighted average remaining life of warrants Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Outstanding Weighted Average Remaining Contractual Terms Share based compensation arrangement by share based payment award increase in number of shares reserved for issuance percentage. Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table] Award Type Award Type [Axis] Equity Award Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain] Stock Options Employee Stock Option [Member] 2016 Plan. 2016 Stock Incentive Plan Two Thousand Sixteen Equity Incentive Plan [Member] 2011 Plan. 2011 Stock Incentive Plan Two Thousand Eleven Stock Incentive Plan [Member] Two thousands and sixteen employee stock purchase plan. 2016 Employee Stock Purchase Plan Two Thousands And Sixteen Employee Stock Purchase Plan [Member] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Shares common stock reserved for issuance Common Stock Capital Shares Reserved For Future Issuance Share based compensation arrangement description Share Based Compensation Arrangement By Share Based Payment Award Description Annual increase of common stock reserved for issuance Share Based Compensation Arrangement By Share Based Payment Award Increase In Number Of Shares Reserved For Issuance Percentage Number of shares grants Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross Option to purchase common stock shares outstanding Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number Weighted average exercise price Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price Shares available for future grant Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant Increase in common stock for future issuance, shares Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Authorized Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Income Statement Location Income Statement Location [Axis] Income Statement Location Income Statement Location [Domain] Research and Development Research And Development Expense [Member] General and Administrative General And Administrative Expense [Member] Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items] Share-based compensation expense Allocated Share Based Compensation Expense Expected term (years) Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1 Expected stock price volatility Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Risk-free interest rate Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate Expected dividend yield Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate Number of Shares, Options outstanding, Beginning balance Number of Shares, Granted Number of Shares, Exercised Number of Shares, Cancelled/Forfeited Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period Number of Shares, Options outstanding, Ending balance Number of Shares, Options exercisable Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number Weighted Average Exercise Price, Options outstanding, Beginning balance Weighted Average Exercise Price, Granted Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price Weighted Average Exercise Price, Exercised Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price Weighted Average Exercise Price, Cancelled/Forfeited Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price Weighted Average Exercise Price, Options outstanding, Ending balance Weighted Average Exercise Price, Options exercisable Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price Schedule Of Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range [Table] Schedule Of Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range [Table] Exercise Price Range Share Based Compensation Shares Authorized Under Stock Option Plans By Exercise Price Range [Axis] Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Domain] Range one. $0.02 - $0.40 Range One [Member] Range two. $3.08 - $5.89 Range Two [Member] Range three. $6.16 - $8.90 Range Three [Member] Range four. $9.11 - $20.84 Range Four [Member] Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items] Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range [Line Items] Exercise Price Lower Range Limit Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range Lower Range Limit Exercise Price Upper Range Limit Share Based Compensation Shares Authorized Under Stock Option Plans Exercise Price Range Upper Range Limit Options Outstanding Weighted Average Exercise Price Aggregate Intrinsic Value Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value Weighted Average Remaining Contractual Life (Years) Sharebased Compensation Shares Authorized Under Stock Option Plans Exercise Price Range Outstanding Options Weighted Average Remaining Contractual Term2 Options Exercisable Weighted Average Exercise Price Aggregate Intrinsic Value Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1 Weighted Average Remaining Contractual Life (Years) Sharebased Compensation Shares Authorized Under Stock Option Plans Exercise Price Range Exercisable Options Weighted Average Remaining Contractual Term2 Unrecognized compensation expense related to unvested stock options Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options Expected to be recognized over a weighted average period Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1 Weighted-average fair values granted Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value Fair market value per share of common stock Sharebased Compensation Arrangement By Sharebased Payment Award Options Nonvested Weighted Average Grant Date Fair Value Employee stock purchase plan payroll deduction as percentage of regular employee earnings maximum. Common stock available for issuance increase in period. Addition of common stock shares reserved for future issuance. Employee payroll deductions, percent Employee Stock Purchase Plan Payroll Deduction As Percentage Of Regular Employee Earnings Maximum Number of shares reserved for issuance increase in years Common Stock Available For Issuance Increase In Period Addition of common stock shares reserved for future issuance Addition Of Common Stock Shares Reserved For Future Issuance Common stock purchased Income tax disclosure line items. Income tax disclosure table. Income Tax Disclosure [Table] Income Tax Disclosure [Table] Income Tax Authority Income Tax Authority [Axis] Income Tax Authority Income Tax Authority [Domain] US federal state income tax. U.S. Federal or State Income Taxes U S Federal State Income Tax [Member] Federal Domestic Country [Member] State State And Local Jurisdiction [Member] Tax Period Tax Period [Axis] Tax Period Tax Period [Domain] Earliest Tax Year Earliest Tax Year [Member] Income Tax Disclosure [Line Items] Income Tax Disclosure [Line Items] Provision for income taxes Income Tax Expense Benefit Deferred tax assets tax non deductible accruals accrued expenses. Deferred tax assets depreciation differences. Operating Loss Carryforwards [Table] Operating Loss Carryforwards [Table] Operating Loss Carryforwards [Line Items] Operating Loss Carryforwards [Line Items] Deferred tax asset (liability) Components Of Deferred Tax Assets And Liabilities [Abstract] Net operating loss carryforwards Deferred Tax Assets Operating Loss Carryforwards Deferred tax asset (liability) Non-deductible accrued expenses Deferred Tax Assets Tax Non Deductible Accruals Accrued Expenses Deferred rent Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Deferred Rent Deferred revenue Deferred Tax Assets Deferred Income Stock compensation expense Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost Depreciation differences Deferred Tax Assets Depreciation Differences Tax credits Deferred Tax Assets Tax Credit Carryforwards Charitable contributions Deferred Tax Assets Charitable Contribution Carryforwards Valuation allowance Deferred Tax Assets Valuation Allowance Net deferred tax asset Deferred Tax Assets Liabilities Net U.S. federal tax rate Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate State tax rate Effective Income Tax Rate Reconciliation State And Local Income Taxes Permanent difference and other Effective Income Tax Rate Reconciliation Other Adjustments Tax credit Effective Income Tax Rate Reconciliation Tax Credits Valuation allowance Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance ASC 740-10 Effective Income Tax Rate Reconciliation Prior Year Income Taxes Impact of federal rate change Effective Income Tax Rate Reconciliation Change In Enacted Tax Rate Total income tax provision (benefit) Effective Income Tax Rate Continuing Operations Tax cuts and jobs act of 2017 change in tax rate income tax expense benefit. Tax Cuts and Jobs Act of 2017,Provisional Income Tax Expense Tax Cuts And Jobs Act Of2017 Change In Tax Rate Income Tax Expense Benefit Deferred tax assets, valuation allowance Operating loss carryforwards expiration period. Net operating loss carryforwards Operating Loss Carryforwards Deferred tax assets, operating loss carryforwards Operating loss carryforwards expiration period Operating Loss Carryforwards Expiration Period Operating loss carryforwards, limitations on use Operating Loss Carryforwards Limitations On Use Reserve for tax positions of prior years Unrecognized Tax Benefits Increases Resulting From Prior Period Tax Positions Non-cancelable operating leases expiration month and year. Commitment and Contingencies [Line Items]. Commitment and Contingencies [Table] Commitment And Contingencies [Table] Commitment And Contingencies [Table] Geographical Statement Geographical [Axis] Geographical Segment Geographical [Domain] GEORGIA GEORGIA CALIFORNIA CALIFORNIA Type of Arrangement and Non-arrangement Transactions Type Of Arrangement [Axis] Arrangements and Non-arrangement Transactions Arrangements And Nonarrangement Transactions [Member] Manufacturing Supply Agreement Member. Manufacturing Supply Agreement Manufacturing Supply Agreement [Member] Gerresheimer regensburg GmbH. Gerresheimer Regensburg GmbH Gerresheimer Regensburg Gmb H [Member] Commitment And Contingencies [Line Items] Commitment And Contingencies [Line Items] Non-cancelable operating leases, expiration date Non Cancelable Operating Leases Expiration Month And Year Base annual rental income fixed percentage increase. Operating leases rent expense minimum rentals per month. Square footage of leased office space. Area of office leased Area Of Leased Office Space Operating lease agreement term Lessee Operating Lease Term Of Contract Operating lease agreement renewal option term Lessee Operating Lease Renewal Term Minimum monthly lease payments Operating Leases Rent Expense Minimum Rentals Per Month Percentage of increase per year Base Annual Rental Income Fixed Percentage Increase 2019 Operating Leases Future Minimum Payments Due Current 2020 Operating Leases Future Minimum Payments Due In Two Years 2021 Operating Leases Future Minimum Payments Due In Three Years 2022 Operating Leases Future Minimum Payments Due In Four Years 2023 Operating Leases Future Minimum Payments Due In Five Years Total minimum lease payments Operating Leases Future Minimum Payments Due Rent expense Lease And Rental Expense Initial Term of Agreement. Renewal Term of Agreement. Initial term of agreement Initial Term Of Agreement Renewal term of agreement Renewal Term Of Agreement Patents expiration period. Schedule Of Research And Development Arrangement Contract To Perform For Others [Table] Schedule Of Research And Development Arrangement Contract To Perform For Others [Table] Legal Entity Legal Entity [Axis] Entity Entity [Domain] NovaMedica LLC NovaMedica Nova Medica L L C [Member] Deferred Revenue Arrangement Type Deferred Revenue Arrangement Type [Axis] Deferred Revenue Deferred Revenue Arrangement Type [Domain] Upfront payment Up Front Payment Arrangement [Member] Product and Service Product Or Service [Axis] Product and Service Products And Services [Domain] License License [Member] Spark Therapeutics, Inc. Spark Therapeutics, Inc. Spark Therapeutics Inc [Member] Collaboration Agreements License And Service [Member] Research And Development Arrangement Contract To Perform For Others [Line Items] Research And Development Arrangement Contract To Perform For Others [Line Items] Deferred revenue Deferred Revenue Revenue Patent expirations period Patents Expiration Period Non refundable payment received. Upfront, non-refundable payment Non Refundable Payment Received Investments Debt And Equity Securities [Abstract] Schedule Of Available For Sale Securities [Table] Schedule Of Available For Sale Securities [Table] Investment Type Investment Type [Axis] Investments Investment Type Categorization [Member] Commercial Paper Commercial Paper [Member] Treasury Bills U S Treasury Bill Securities [Member] Schedule of Available-for-sale Securities [Line Items] Schedule Of Available For Sale Securities [Line Items] Amortized Cost Available For Sale Debt Securities Amortized Cost Basis Unrealized Loss Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax Fair Value Fair value assets between level 1 level 2 and level 3 transfers amount. Significant transfers between Levels 1, 2 and 3 Fair Value Assets Between Level1 Level2 And Level3 Transfers Amount Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Asset Class Fair Value By Asset Class [Axis] Asset Class Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain] Cash and money markets. Cash and Money Markets Cash And Money Markets [Member] Restricted cash money market. Restricted Cash Money Market Restricted Cash Money Market [Member] Certificates of Deposit Certificates Of Deposit [Member] Fair Value Hierarchy and NAV Fair Value By Fair Value Hierarchy Level [Axis] Fair Value Hierarchy and NAV Fair Value Measurements Fair Value Hierarchy [Domain] Level 1 Fair Value Inputs Level1 [Member] Level 2 Fair Value Inputs Level2 [Member] Level 3 Fair Value Inputs Level3 [Member] Government Bonds and Treasury Bills U S Treasury And Government [Member] Corporate Bonds Corporate Bond Securities [Member] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Financial Assets: Assets Fair Value Disclosure [Abstract] Total financial assets Assets Fair Value Disclosure Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Antidilutive Securities Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis] Antidilutive Securities, Name Antidilutive Securities Name [Domain] Outstanding Stock Options Stock Purchase Warrants Warrant [Member] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Antidilutive securities excluded from computation of earnings per share Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount Operating expenses