UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549	 	 	

 	SCHEDULE 13G
 	 	
 	Under the Securities Exchange Act of 1934
 	 	
 	(Amendment No. 1)*	 	

 	Clearside Biomedical, Inc.	 	
 	(Name of Issuer)	 	

 	Common Stock, par value $0.001 per share	 	
 	(Title of Class of Securities)	 	

 	15063104	 	
 	(CUSIP Number)	 	

 	December 31, 2016	 	
 	(Date of Event which Requires Filing of this Statement)	 	

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
[ ]            Rule 13d-1(b)
[x]            Rule 13d-1(c)
[ ]            Rule 13d-1(d)
___________________________________
*  The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,  see  the Notes).

 
1	 
Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only)
 
Cormorant Global Healthcare Master Fund, LP

2	 
Check the Appropriate Box if a Member of a Group (See Instructions)	 	
 	 
(a)            [ ]	 	
 	 
(b)            [x]	 	
 
3	 
SEC Use Only	 	
 
4	 
Citizenship or Place of Organization.
 
Cayman Islands

Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With	 
5  Sole Voting Power
 
0 shares

6  Shared Voting Power
 
1,945,255 shares
 
Refer to Item 4 below.	 	 	 	
 	 
7  Sole Dispositive Power
 
0 shares

8  Shared Dispositive Power
 
1,945,255 shares
 
Refer to Item 4 below.	 	 	 	 	 	 	
 
9	 
Aggregate Amount Beneficially Owned by Each Reporting Person
 
1,945,255 shares
 
Refer to Item 4 below.	 	 	 	 	 	 	 	
 
10	 
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)     [ ] N/A	 	 	 	 	 	 	 	
 
11	 
Percent of Class Represented by Amount in Row (9)*
 
7.8%
 
Refer to Item 4 below.	 	 	 	 	 	 	 	
 
12	 
Type of Reporting Person (See Instructions)
 
PN (Partnership)

 
1	 
Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only)
 
Cormorant Global Healthcare GP, LLC

2	 
Check the Appropriate Box if a Member of a Group (See Instructions)	 	
 	 
(a)            [ ]	 	
 	 
(b)            [x]	 	
 
3	 
SEC Use Only	 	
 
4	 
Citizenship or Place of Organization.
 
Delaware

Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With	 
5  Sole Voting Power
 
0 shares

6  Shared Voting Power
 
1,945,255 shares

Refer to Item 4 below.	 	 	 	
 	 
7  Sole Dispositive Power
 
0 shares

8  Shared Dispositive Power
 
1,945,255 shares

Refer to Item 4 below.	 	 	 	 	 	 	
 
9	 
Aggregate Amount Beneficially Owned by Each Reporting Person
 
1,945,255 shares

Refer to Item 4 below.	 	 	 	 	 	 	 	
 
10	 
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)     [ ] N/A	 	 	 	 	 	 	 	
 
11	 
Percent of Class Represented by Amount in Row (9)*
 
7.8%
 
Refer to Item 4 below.	 	 	 	 	 	 	 	
 
12	 
Type of Reporting Person (See Instructions)
 
OO (Limited Liability Company)

 
1	 
Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only)
 
Cormorant Asset Management, LLC

2	 
Check the Appropriate Box if a Member of a Group (See Instructions)	 	
 	 
(a)            [ ]	 	
 	 
(b)            [x]	 	
 
3	 
SEC Use Only	 	
 
4	 
Citizenship or Place of Organization.
 
Delaware

Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With	 
5  Sole Voting Power
 
0 shares

6  Shared Voting Power
 
2,333,333 shares
 
Refer to Item 4 below.	 	 	 	
 	 
7  Sole Dispositive Power
 
0 shares

8  Shared Dispositive Power
 
2,333,333 shares
 
Refer to Item 4 below.	 	 	 	 	 	 	
 
9	 
Aggregate Amount Beneficially Owned by Each Reporting Person
 
2,333,333 shares
 
Refer to Item 4 below.	 	 	 	 	 	 	 	
 
10	 
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)     [ ] N/A	 	 	 	 	 	 	 	
 
11	 
Percent of Class Represented by Amount in Row (9)*
 
9.4%
 
Refer to Item 4 below.	 	 	 	 	 	 	 	
 
12	 
Type of Reporting Person (See Instructions)
 
OO (Limited Liability Company)

 
1	 
Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only)
 
Bihua Chen

2	 
Check the Appropriate Box if a Member of a Group (See Instructions)	 	
 	 
(a)            [ ]	 	
 	 
(b)            [x]	 	
 
3	 
SEC Use Only	 	
 
4	 
Citizenship or Place of Organization.
 
United States

Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With	 
5  Sole Voting Power
 
0 shares

6  Shared Voting Power
 
2,333,333 shares
 
Refer to Item 4 below.	 	 	 	
 	 
7  Sole Dispositive Power
 
0 shares

8  Shared Dispositive Power
 
2,333,333 shares
 
Refer to Item 4 below.	 	 	 	 	 	 	
 
9	 
Aggregate Amount Beneficially Owned by Each Reporting Person
 
2,333,333 shares
 
Refer to Item 4 below.	 	 	 	 	 	 	 	
 
10	 
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)     [ ] N/A	 	 	 	 	 	 	 	
 
11	 
Percent of Class Represented by Amount in Row (9)*
 
9.4%
 
Refer to Item 4 below.	 	 	 	 	 	 	 	
 
12	 
Type of Reporting Person (See Instructions)
 
IN (Individual)

Item 1.
(a)	Name of Issuer	
 	 
Clearside Biomedical, Inc.
 	
(b)	Address of Issuer’s Principal Executive Offices	
 	 
1220 Old Alpharetta Road, Suite 300
Alpharetta, GA 30005	

Item 2.
(a)	Name of Person Filing	
 	 
Cormorant Global Healthcare Master Fund, LP
Cormorant Global Healthcare GP, LLC
Cormorant Asset Management, LLC
Bihua Chen
 	
(b)	Address of Principal Business Office or, if none, Residence	
 	 
200 Clarendon Street, 52nd Floor
Boston, MA 02116
 	
(c)	Citizenship	
 	 
Cormorant Global Healthcare Master Fund, LP - Cayman Islands
Cormorant Global Healthcare GP, LLC - Delaware
Cormorant Asset Management, LLC - Delaware
Bihua Chen - United States
 	
(d)	Title of Class of Securities	
 	 
Common Stock
 	
(e)	CUSIP Number
15063104	

Item 3.	If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:	
(a)
 	[ ]
 	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
 	
(b)
 	[ ]
 	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
 	
(c)
 	[ ]
 	Insurance Company as defined in Section 3(a)(19) of the Act
 	
(d)
 	[ ]
 	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
 	
(e)
 	[ ]
 	An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);
 	
(f)
 	[ ]
 	An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);
 	
(g)
 	[ ]
 	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
 	
(h)
 	[ ]
 	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
 	
(i)
 	[ ]
 	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
 	
(j)
 	[ ]
 	A non-U.S. institution in accordance with §240.13d–1(b)(1)(ii)(J);
 	
(k)
 	[ ]
 	Group, in accordance with §240.13d-1(b)(1)(ii)(K).

Item 4.	Ownership***	
Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.
(a)	Amount Beneficially Owned***	
 	 
Cormorant Global Healthcare Master Fund, LP – 1,945,255 shares
Cormorant Global Healthcare GP, LLC - 1,945,255 shares
Cormorant Asset Management, LLC - 2,333,333 shares
Bihua Chen - 2,333,333 shares
 	
(b)	Percent of Class	
 	Cormorant Global Healthcare Master Fund, LP – 7.8%
Cormorant Global Healthcare GP, LLC – 7.8%
Cormorant Asset Management, LLC – 9.4%
Bihua Chen – 9.4%
 	
(c)	Number of shares as to which such person has:
 	
 	(i)	sole power to vote or to direct the vote	
 	 	 
Cormorant Global Healthcare Master Fund, LP - 0 shares
Cormorant Global Healthcare GP, LLC - 0 shares
Cormorant Asset Management, LLC - 0 shares
Bihua Chen - 0 shares
 	
 	(ii)	shared power to vote or to direct the vote	
 	 	 
Cormorant Global Healthcare Master Fund, LP – 1,945,255 shares
Cormorant Global Healthcare GP, LLC - 1,945,255 shares
Cormorant Asset Management, LLC - 2,333,333 shares
Bihua Chen - 2,333,333 shares
 	
 	(iii)	sole power to dispose or to direct the disposition of	
 	 	 
Cormorant Global Healthcare Master Fund, LP - 0 shares
Cormorant Global Healthcare GP, LLC - 0 shares
Cormorant Asset Management, LLC - 0 shares
Bihua Chen - 0 shares
 	
 	(iv)	shared power to dispose or to direct the disposition of	
 	 	 
Cormorant Global Healthcare Master Fund, LP – 1,945,255 shares
Cormorant Global Healthcare GP, LLC - 1,945,255 shares
Cormorant Asset Management, LLC - 2,333,333 shares
Bihua Chen - 2,333,333 shares	

*** Shares reported herein for Cormorant Asset Management, LLC represent shares which are beneficially owned by Cormorant Global Healthcare Master Fund, LP (the “Fund”), as reported herein, and shares which are beneficially owned by a managed account (the “Account”).  Shares represented herein for the Fund represent 1,624,364 shares and 320,891 shares issuable upon the exercise of preferred shares held by the Fund. Shares represented herein for the Account represent 328,089 shares and 59,989 shares issuable upon the exercise of preferred shares held by the Account. Cormorant Global Healthcare GP, LLC serves as the general partner of the Fund, and Cormorant Asset Management, LLC serves as the investment manager to both the Fund and the Account.  Bihua Chen serves as the managing member of Cormorant Global Healthcare GP, LLC and Cormorant Asset Management, LLC. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or his pecuniary interest therein. Percentage calculations herein are based upon there being 24,545,752 issued and outstanding stock as of December 9, 2016 as reported in the Issuer’s Prospectus filed with the SEC on December 9, 2016.

Item 5.  Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [  ].
Item 6.  Ownership of More than Five Percent on Behalf of Another Person
Not applicable.
Item 7.  Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company
Not applicable.
Item 8.	Identification and Classification of Members of the Group	
Not applicable.
Item 9.	Notice of Dissolution of Group	
Not applicable.
Item 10.	Certification	
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this Statement is true, complete and correct.
February 14, 2017

CORMORANT GLOBAL HEALTHCARE MASTER FUND, LP
By: Cormorant Global Healthcare GP, LLC
its General Partner

By: /s/ Bihua Chen
Bihua Chen, Managing Member

CORMORANT GLOBAL HEALTHCARE GP, LLC

By: /s/ Bihua Chen
Bihua Chen, Managing Member

CORMORANT ASSET MANAGEMENT, LLC

By: /s/ Bihua Chen
Bihua Chen, Managing Member

/s/ Bihua Chen
Bihua Chen

Exhibit 1
JOINT FILING AGREEMENT
This Joint Filing Agreement, dated as of February 14, 2017, is by and among Cormorant Global Healthcare Master Fund, LP, Cormorant Global Healthcare GP, LLC, Cormorant Asset Management, LLC and Bihua Chen (collectively, the “Filers”).
Each of the Filers may be required to file with the United States Securities and Exchange Commission a statement on Schedule 13D and/or 13G with respect to shares of Common Stock of Clearside Biomedical, Inc. beneficially owned by them  from time to time.

Pursuant to and in accordance with Rule 13(d)(1)(k) promulgated under the Securities Exchange Act of 1934, as amended, the Filers hereby agree to file a single statement on Schedule 13D and/or 13G (and any amendments thereto) on behalf of each of the Filers, and hereby further agree to file this Joint Filing Agreement as an exhibit to such statement, as required by such rule.

This Joint Filing Agreement may be terminated by any of the Filers upon written notice or such lesser period of notice as the Filers may mutually agree.

Executed and delivered as of the date first above written.

CORMORANT GLOBAL HEALTHCARE MASTER FUND, LP
By: Cormorant Global Healthcare GP, LLC
its General Partner

By: /s/ Bihua Chen                                                                            
Bihua Chen, Managing Member

CORMORANT GLOBAL HEALTHCARE GP, LLC

By: /s/ Bihua Chen                                                                            
Bihua Chen, Managing Member

CORMORANT ASSET MANAGEMENT, LLC

By: /s/ Bihua Chen                                                                            
Bihua Chen, Managing Member

/s/ Bihua Chen                                                              
Bihua Chen