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  <xsd:element id="clsd_LicenseAndOtherAgreementAbstract" name="LicenseAndOtherAgreementAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_ReconciliationOfCashCashEquivalentsAndRestrictedCashAbstract" name="ReconciliationOfCashCashEquivalentsAndRestrictedCashAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_StockPurchaseWarrantsAbstract" name="StockPurchaseWarrantsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_AccretionOfFinalPaymentOfAmountBorrowed" name="AccretionOfFinalPaymentOfAmountBorrowed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clsd_AccruedResearchAndDevelopmentExpenses" name="AccruedResearchAndDevelopmentExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clsd_AccruedSeveranceCosts" name="AccruedSeveranceCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clsd_AdditionalFeesForExpansionToExistingLicense" name="AdditionalFeesForExpansionToExistingLicense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_AdditionalMilestonePayment" name="AdditionalMilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_AreaOfLeasedOfficeSpace" name="AreaOfLeasedOfficeSpace" type="num:areaItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clsd_BaseAnnualRentalIncomeFixedPercentageIncrease" name="BaseAnnualRentalIncomeFixedPercentageIncrease" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clsd_DevelopmentMilestonePayments" name="DevelopmentMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_EligiblePayrollCosts" name="EligiblePayrollCosts" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clsd_EstimatedProceedsFromLicenseFeesReceived" name="EstimatedProceedsFromLicenseFeesReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_FairValueAssetsBetweenLevel1Level2AndLevel3TransfersAmount" name="FairValueAssetsBetweenLevel1Level2AndLevel3TransfersAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_FirstCumulativeNetSalesOfProducts" name="FirstCumulativeNetSalesOfProducts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clsd_ForgivenessOfPaycheckProtectionProgramLoanAndAccruedInterest" name="ForgivenessOfPaycheckProtectionProgramLoanAndAccruedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_IncrementalBorrowingRate" name="IncrementalBorrowingRate" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clsd_IssuanceOfCommonSharesUnderADirectRegisteredOffering" name="IssuanceOfCommonSharesUnderADirectRegisteredOffering" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clsd_IssuanceOfCommonStockValueUnderADirectRegisteredOffering" name="IssuanceOfCommonStockValueUnderADirectRegisteredOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clsd_LineOfCreditFacilityRemainingBorrowingCapacityNotAvailableForWithdraw" name="LineOfCreditFacilityRemainingBorrowingCapacityNotAvailableForWithdraw" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clsd_MilestonePaymentsReceived" name="MilestonePaymentsReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clsd_NetProceedsAfterDeductingOfferingExpenses" name="NetProceedsAfterDeductingOfferingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clsd_NetProceedsFromIssuanceOfStock" name="NetProceedsFromIssuanceOfStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_OperatingLeaseImputedInterest" name="OperatingLeaseImputedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_OperatingLeasesRentExpenseMinimumRentalsPerMonth" name="OperatingLeasesRentExpenseMinimumRentalsPerMonth" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_PreLaunchMilestonePayments" name="PreLaunchMilestonePayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_PrepaymentFeePercentageOfOriginalPrincipalAmountOfTermLoans" name="PrepaymentFeePercentageOfOriginalPrincipalAmountOfTermLoans" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="clsd_ProceedsFromIssuanceAtTheMarket" name="ProceedsFromIssuanceAtTheMarket" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="clsd_ScheduleOfOperatingLeasesAssetsAndLiabilities" name="ScheduleOfOperatingLeasesAssetsAndLiabilities" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clsd_StockIssuedDuringPeriodSharesAtMarketSalesAgreement" name="StockIssuedDuringPeriodSharesAtMarketSalesAgreement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clsd_StockIssuedDuringPeriodValueAtMarketSalesAgreement" name="StockIssuedDuringPeriodValueAtMarketSalesAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="clsd_ThresholdPercentageOfSalesForTieredRoyalties" name="ThresholdPercentageOfSalesForTieredRoyalties" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clsd_UpfrontPayments" name="UpfrontPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
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  <xsd:element id="clsd_CommitmentAndContingenciesLineItems" name="CommitmentAndContingenciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_ArcticVisionsLimitedMember" name="ArcticVisionsLimitedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_AtTheMarketSalesAgreementMember" name="AtTheMarketSalesAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_BauschHealthIrelandLimitedMember" name="BauschHealthIrelandLimitedMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_CashAndMoneyMarketsMember" name="CashAndMoneyMarketsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_CommercialArrangementMember" name="CommercialArrangementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_CommonStockWarrantsMember" name="CommonStockWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_CowenAndCompanyLlcMember" name="CowenAndCompanyLlcMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_FinalPaymentMember" name="FinalPaymentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_FirstAmendedAndRestatedLoanAndSecurityAgreementMember" name="FirstAmendedAndRestatedLoanAndSecurityAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_LicenseArrangementMember" name="LicenseArrangementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_NonVestedRestrictedStockUnitsMember" name="NonVestedRestrictedStockUnitsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_OtherAgreementMember" name="OtherAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_PaycheckProtectionProgramMember" name="PaycheckProtectionProgramMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_RegenxbioIncMember" name="RegenxbioIncMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_RestrictedCashMoneyMarketMember" name="RestrictedCashMoneyMarketMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_SecondAmendedAndRestatedLoanAndSecurityAgreementFirstTrancheMember" name="SecondAmendedAndRestatedLoanAndSecurityAgreementFirstTrancheMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_SecondAmendedAndRestatedLoanAndSecurityAgreementMember" name="SecondAmendedAndRestatedLoanAndSecurityAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_SiliconValleyBankMember" name="SiliconValleyBankMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_SiliconValleyBankMidCapFundingIIITrustAndMidCapFinancialTrustMember" name="SiliconValleyBankMidCapFundingIIITrustAndMidCapFinancialTrustMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_SiliconValleyBankMidCapFundingXIITrustAndMidCapFinancialTrustMember" name="SiliconValleyBankMidCapFundingXIITrustAndMidCapFinancialTrustMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_TwoThousandsAndElevenStockIncentivePlanTwoThousandsAndSixteenEquityIncentivePlanMember" name="TwoThousandsAndElevenStockIncentivePlanTwoThousandsAndSixteenEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_TwoThousandSixteenEmployeeStockPurchasePlanMember" name="TwoThousandSixteenEmployeeStockPurchasePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_UpfrontPaymentMember" name="UpfrontPaymentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_XipereMember" name="XipereMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_RisksAndUncertaintiesPolicyTextBlock" name="RisksAndUncertaintiesPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clsd_UnauditedInterimFinancialInformationPolicyTextBlock" name="UnauditedInterimFinancialInformationPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clsd_CommitmentAndContingenciesTable" name="CommitmentAndContingenciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="clsd_CARESActPaycheckProtectionProgramLoanTextBlock" name="CARESActPaycheckProtectionProgramLoanTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clsd_LicenseAndOtherAgreementsDisclosureTextBlock" name="LicenseAndOtherAgreementsDisclosureTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="clsd_StockPurchaseWarrantsDisclosureTextBlock" name="StockPurchaseWarrantsDisclosureTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
</xsd:schema>
